{"id":5436,"date":"2023-10-16T17:45:59","date_gmt":"2023-10-16T15:45:59","guid":{"rendered":"https:\/\/amoeba-nature.com\/?p=5436"},"modified":"2023-10-16T17:51:10","modified_gmt":"2023-10-16T15:51:10","slug":"amoeba-potential-use-of-amoeba-lysate-in-cosmetics","status":"publish","type":"post","link":"https:\/\/amoeba-nature.com\/en\/amoeba-potential-use-of-amoeba-lysate-in-cosmetics\/","title":{"rendered":"AMOEBA\u00a0: Convincing results for the use of\u00a0amoeba lysate in cosmetics."},"content":{"rendered":"<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<h1 class=\"wp-block-heading has-text-align-center\">AMOEBA&nbsp;: Convincing results for the use of&nbsp;<em>Willaertia magna<\/em>&nbsp;C2c Maky lysate in cosmetics.<\/h1>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<p><strong>Chassieu (France), October 16, 2023 &#8211; 17h45 &#8211;<\/strong>&nbsp;<strong>AMO\u00c9BA (FR0011051598 \u2013 ALMIB)<\/strong>&nbsp;an industrial biotech in pre-commercialization* specialised in the treatment of microbiological risk, developing a biocontrol agent for the crop treatment in agriculture that has obtained a marketing authorization in the United States and a biological biocide that has also obtained a marketing authorisation in the United States for use in closed cooling systems, announces that it has obtained convincing results for the use of&nbsp;<em>Willaertia magna<\/em>&nbsp;C2c Maky lysate in cosmetic skin care and has filed a patent application for this invention.<\/p>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<p>As part of its research for new applications, the Company unexpectedly discovered that the&nbsp;<em>Willaertia magna<\/em>&nbsp;C2c Maky lysate could be of cosmetic interest. To validate this use, two studies were conducted by specialized laboratories and the below-described conclusive results led the Company to fill a patent to protect the use of the lysate as a cosmetic ingredient.<\/p>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<p><em><strong>First study: Induction of genes of cosmetic interest<\/strong><\/em><\/p>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<p>The first study was carried out by a specialized external laboratory with the aim of assessing the level of induction of target genes of cosmetic interest after lab-grown human skin cells were treated with the&nbsp;<em>Willaertia magna<\/em>&nbsp;C2c Maky lysate.<\/p>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<p>The results showed that treating human cells with&nbsp;<a><em>Willaertia magna<\/em>&nbsp;C2c Maky lysate&nbsp;<\/a>stimulated cellular functions of importance in cosmetics:&nbsp;<\/p>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<ul class=\"wp-block-list\"><div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<li>Moderate stimulation of the expression of cellular functions involved in wound healing (<em>FBL5<\/em>&nbsp;gene), hyaluronic acid synthesis (<em>HAS<\/em>&nbsp;gene) and anti-infectious immunity (<em>TLR2<\/em>&nbsp;gene).<\/li>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<li>Very strong stimulation of the expression of cellular functions protecting against cell death (<em>BCL2<\/em>&nbsp;gene), cell renewal (<em>PIWIL1<\/em>&nbsp;gene) and UV protection, anti-oxidative stress and photoaging (<em>FOXO1<\/em>&nbsp;and&nbsp;<em>SGK1<\/em>&nbsp;genes).&nbsp;<\/li>\n<\/div><\/div><\/div><\/ul>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<p>These results, demonstrating the induction of multiple genes of cosmetic interest, led the Company to evaluate the effect of&nbsp;<em>Willaertia magna<\/em>&nbsp;C2c Maky lysate on a 3-dimensional (3D) skin model.<\/p>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<p><em><strong>Second study: Evaluation of the effect of the lysate on a 3D skin model<\/strong><\/em><\/p>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<p>This study was carried out by LabSkin Creations, a biotechnology company specialised in advanced 3D skin engineering and service provider to the world&#8217;s leading cosmetics brands.<em>Willaertia magna<\/em>&nbsp;C2c Maky lysate was applied every 2-3 days for 30 days to the LabSkin 3D reconstructed skin model to assess the effect of the lysate on ageing skin. Part of the tissue&nbsp;constructs was exposed to 100 mJ\/cm<sub>2<\/sub>&nbsp;of UV<sub>B<\/sub>&nbsp;to assess the level of protection induced by the lysate against the UV<sub>B<\/sub>&nbsp;effects.&nbsp;<\/p>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<p>The results on the 3D model of ageing skin and on the 3D young skin model under UV<sub>B<\/sub>&nbsp;exposure showed that, compared with the untreated conditions, treatment with&nbsp;<em>Willaertia magna<\/em>&nbsp;C2c Maky lysate increased epidermal thickness, led to recovery of terminal cell differentiation and improved the quality and abundance of the extracellular matrix which is essential for the cohesion of the skin&#8217;s compartments.<\/p>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<p>The amoeba lysate could therefore be used as a cosmetic ingredient for the following cosmetic purposes:<\/p>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<ul class=\"wp-block-list\"><div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<li>protection against cell death of skin cells,&nbsp;<\/li>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<li>cellular renewal of skin cells,&nbsp;<\/li>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<li>protection against the effects of UV rays,<\/li>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<li>anti oxidative stress,&nbsp;<\/li>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<li>protection against photoaging.&nbsp;<\/li>\n<\/div><\/div><\/div><\/ul>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<p>The next step, planned over the coming months, will consist of carrying out a test formulation for cosmetic trials on volunteers by specialized companies.<\/p>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<p><em><strong>Intellectual property and regulatory requirements<\/strong><\/em><\/p>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<p>The Company has filed today a patent with the French Patent Office (Institut national de la propri\u00e9t\u00e9 industrielle) entitled &#8221;&nbsp;<em>Cosmetic composition containing protozoan<\/em>\u201d to protect the invention of a cosmetic composition for skin care including protozoa of the genus&nbsp;<em>Willaertia<\/em>.<\/p>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<p><strong>At regulatory level, in Europe and the United States, the placing on the market of a cosmetic product does not require prior approval by a competent authority<\/strong>: the person responsible for placing the&nbsp;formulated cosmetic product&nbsp;on the market must carry out a self-assessment of the product safety.&nbsp;<\/p>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<p>Amo\u00e9ba could provide the cosmetic industry with an ingredient whose absence of hazard has been validated by all the regulatory studies carried out for the biocontrol application, the cosmetic ingredient being identical to the biocontrol active substance.<\/p>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<p><em>\u201cWe are very proud of this discovery and of these excellent proof-of-concept results, which once again demonstrate the expertise of our biotechnology and industrial valorisation platform. The cosmetics market is a fast-growing industry that has been called into question in recent years because of the chemical origin and the health and environmental impacts of its ingredients. Once incorporated into a cosmetic formulation, this new cosmetic ingredient, with its many beneficial effects, can provide a multifunctional natural product. The ingredient can be mass-produced using our existing industrial facilities with a high standard of quality<\/em>.\u201d, says Fabrice PLASSON, CEO of Amo\u00e9ba.<\/p>\n<\/div><\/div><\/div>\n\n<div class=\"container\"><div class=\"row\"><div class=\"medium-large-full\">\n<p><a href=\"https:\/\/amoeba-nature.com\/wp-content\/uploads\/2023\/10\/ENG-CP-Brevet-Cosmetique-20231013-VDEF.pdf\">Read the press release in PDF<\/a><\/p>\n<\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>AMOEBA&nbsp;: Convincing results for the use of&nbsp;Willaertia magna&nbsp;C2c Maky lysate in cosmetics. Chassieu (France), October 16, 2023 &#8211; [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":5428,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[12],"tags":[],"class_list":["post-5436","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>AMOEBA\u00a0: Convincing results for the use of\u00a0amoeba lysate in cosmetics. - Amoeba<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amoeba-nature.com\/en\/amoeba-potential-use-of-amoeba-lysate-in-cosmetics\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AMOEBA\u00a0: Convincing results for the use of\u00a0amoeba lysate in cosmetics. - Amoeba\" \/>\n<meta property=\"og:description\" content=\"AMOEBA&nbsp;: Convincing results for the use of&nbsp;Willaertia magna&nbsp;C2c Maky lysate in cosmetics. 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